Rasgrp1 (NM_011246) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR210704L3V
- LentiORF®
Lenti ORF particles, Rasgrp1 (Myc-DDK-tagged) - Mouse RAS guanyl releasing protein 1 (Rasgrp1), 200ul, >10^7 TU/mL
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CNY 12,920.00
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Specifications
Product Data | |
Product Name | Rasgrp1 (NM_011246) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | Rasgrp |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_011246 |
ORF Size | 2385 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR210704).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_011246.2 |
RefSeq Size | 5155 bp |
RefSeq ORF | 2388 bp |
Locus ID | 19419 |
Gene Summary | Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (PubMed:17190838). May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (PubMed:15829980, PubMed:17210708).[UniProtKB/Swiss-Prot Function] |
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