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Ulk2 (BC053029) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211498L3V
- LentiORF®
-
Lenti ORF particles, Ulk2 (Myc-DDK-tagged) - Mouse Unc-51 like kinase 2 (C. elegans) (cDNA clone MGC:62255 IMAGE:5709559), 200ul, >10^7 TU/mL
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CNY 15,200.00
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Specifications
| Product Data | |
| Product Name | Ulk2 (BC053029) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Unc51.2, mKIAA0623 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC053029 |
| ORF Size | 3111 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211498).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC053029.1 |
| RefSeq Size | 4413 bp |
| RefSeq ORF | 3113 bp |
| Locus ID | 29869 |
| Gene Summary | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.[UniProtKB/Swiss-Prot Function] |
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