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Ubr2 (BC031403) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211646L3V
- LentiORF®
-
Lenti ORF particles, Ubr2 (Myc-DDK-tagged) - Mouse ubiquitin protein ligase E3 component n-recognin 2 (cDNA clone MGC:36320 IMAGE:4935220), 200ul, >10^7 TU/mL
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CNY 15,200.00
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Specifications
| Product Data | |
| Product Name | Ubr2 (BC031403) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | MGC36320 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC031403 |
| ORF Size | 3327 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211646).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC031403.1 |
| RefSeq Size | 3502 bp |
| RefSeq ORF | 3329 bp |
| Locus ID | 224826 |
| Gene Summary | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (PubMed:28708824). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retranstoposon mobilization (PubMed:28806172).[UniProtKB/Swiss-Prot Function] |
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