Klhl15 (NM_001039061) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR213950L3V
- LentiORF®
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Lenti ORF particles, Klhl15 (Myc-DDK-tagged) - Mouse kelch-like 15 (Drosophila) (Klhl15), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 10,735.00
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Specifications
Product Data | |
Product Name | Klhl15 (NM_001039061) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | 6330500C13Rik |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001039061 |
ORF Size | 1812 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR213950).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001039061.1, NP_001034150.1 |
RefSeq Size | 2363 bp |
RefSeq ORF | 1815 bp |
Locus ID | 236904 |
Gene Summary | Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).[UniProtKB/Swiss-Prot Function] |
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