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Rbm15 (NM_001045807) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR215320L3V
- LentiORF®
-
Lenti ORF particles, Rbm15 (Myc-DDK-tagged) - Mouse RNA binding motif protein 15 (Rbm15), 200ul, >10^7 TU/mL
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CNY 14,820.00
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Specifications
| Product Data | |
| Product Name | Rbm15 (NM_001045807) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | C230088J01Rik; mKIAA1438 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001045807 |
| ORF Size | 2889 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR215320).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001045807.1, NP_001039272.1 |
| RefSeq Size | 3270 bp |
| RefSeq ORF | 2889 bp |
| Locus ID | 229700 |
| Gene Summary | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:29535189). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:29535189). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (By similarity). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (PubMed:17283045, PubMed:17376872, PubMed:18981216, PubMed:25468569). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (By similarity). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (PubMed:18981216). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (PubMed:25468569). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (By similarity). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (By similarity). May be implicated in HOX gene regulation (By similarity).[UniProtKB/Swiss-Prot Function] |
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