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Otop1 (NM_172709) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR219221L4V
- LentiORF®
-
Lenti ORF particles, Otop1 (GFP-tagged) - Mouse otopetrin 1 (Otop1), 200ul, >10^7 TU/mL
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CNY 11,875.00
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Specifications
| Product Data | |
| Product Name | Otop1 (NM_172709) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | A530025J20Rik; Otp1; tlt |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_172709 |
| ORF Size | 1800 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR219221).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_172709.3, NP_766297.2 |
| RefSeq Size | 3171 bp |
| RefSeq ORF | 1803 bp |
| Locus ID | 21906 |
| Gene Summary | Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly-sensitive to voltage (PubMed:29371428). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (PubMed:12651873). Probably acts by maintaining the pH appropriate for formation of otoconia (PubMed:29371428). Regulates purinergic control of intracellular calcium in vestibular supporting cells (PubMed:17606897, PubMed:20554841). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (PubMed:29371428). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (PubMed:24379350).[UniProtKB/Swiss-Prot Function] |
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