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Otud4 (NM_001081164) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR222438L4V
- LentiORF®
-
Lenti ORF particles, Otud4 (GFP-tagged) - Mouse OTU domain containing 4 (Otud4), 200ul, >10^7 TU/mL
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CNY 18,240.00
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Specifications
| Product Data | |
| Product Name | Otud4 (NM_001081164) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 4930431L18Rik; AI449692; D8Ertd69e; mKIAA1046 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001081164 |
| ORF Size | 3324 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR222438).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001081164.1, NP_001074633.1 |
| RefSeq Size | 7324 bp |
| RefSeq ORF | 3321 bp |
| Locus ID | 73945 |
| Gene Summary | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity).[UniProtKB/Swiss-Prot Function] |
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