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Chtop (NM_023215) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR222783L3V
- LentiORF®
-
Lenti ORF particles, Chtop (Myc-DDK-tagged) - Mouse RIKEN cDNA 2500003M10 gene (2500003M10Rik), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Chtop (NM_023215) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2500003M10Rik; Fop; Srag |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_023215 |
| ORF Size | 675 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR222783).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_023215.5, NP_075704.2 |
| RefSeq Size | 3721 bp |
| RefSeq ORF | 675 bp |
| Locus ID | 66511 |
| Gene Summary | Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789).[UniProtKB/Swiss-Prot Function] |
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