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Acin1 (NM_019567) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR223236L3V
- LentiORF®
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Lenti ORF particles, Acin1 (Myc-DDK-tagged) - Mouse apoptotic chromatin condensation inducer 1 (Acin1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 11,020.00
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Specifications
| Product Data | |
| Product Name | Acin1 (NM_019567) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2610036I19Rik; 2610510L13Rik; Acinus; acinusL; acinusS; Acn; C79325; mKIAA0670 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_019567 |
| ORF Size | 1902 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR223236).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_019567.3, NP_062513.3 |
| RefSeq Size | 2519 bp |
| RefSeq ORF | 1905 bp |
| Locus ID | 56215 |
| Gene Summary | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (By similarity).[UniProtKB/Swiss-Prot Function] |
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