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Flt3 (NM_010229) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR223373L4V
- LentiORF®
-
Lenti ORF particles, Flt3 (GFP-tagged) - Mouse FMS-like tyrosine kinase 3 (Flt3), 200ul, >10^7 TU/mL
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CNY 16,910.00
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Specifications
| Product Data | |
| Product Name | Flt3 (NM_010229) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | B230315G04; CD135; Flk-2; Flk2; Flt-3; Ly72; wmfl |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_010229 |
| ORF Size | 3000 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR223373).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010229.2, NP_034359.2 |
| RefSeq Size | 3664 bp |
| RefSeq ORF | 3003 bp |
| Locus ID | 14255 |
| Gene Summary | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.[UniProtKB/Swiss-Prot Function] |
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