Gpr161 (NM_001081126) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR224248L3V
- LentiORF®
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Lenti ORF particles, Gpr161 (Myc-DDK-tagged) - Mouse G protein-coupled receptor 161 (Gpr161), 200ul, >10^7 TU/mL
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CNY 10,165.00
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Specifications
Product Data | |
Product Name | Gpr161 (NM_001081126) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | Gm208; Gm208Gpr; vl |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001081126 |
ORF Size | 1677 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR224248).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001081126.1, NP_001074595.1 |
RefSeq Size | 1943 bp |
RefSeq ORF | 1677 bp |
Locus ID | 240888 |
Gene Summary | Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown.[UniProtKB/Swiss-Prot Function] |
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