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Xpo5 (NM_028198) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR225052L4V
- LentiORF®
-
Lenti ORF particles, Xpo5 (GFP-tagged) - Mouse exportin 5 (Xpo5), 200ul, >10^7 TU/mL
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CNY 19,475.00
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Specifications
| Product Data | |
| Product Name | Xpo5 (NM_028198) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2410004H11Rik; 2700038C24Rik; AI648907; AW549301; Exp5; mKIAA1291; RanBp21 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_028198 |
| ORF Size | 3612 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR225052).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_028198.2 |
| RefSeq Size | 3709 bp |
| RefSeq ORF | 3615 bp |
| Locus ID | 72322 |
| Gene Summary | Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi) (By similarity). Mediates nuclear export of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity).[UniProtKB/Swiss-Prot Function] |
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