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Flt4 (NM_008029) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR225313L2V
- LentiORF®
-
Lenti ORF particles, Flt4 (GFP-tagged) - Mouse FMS-like tyrosine kinase 4 (Flt4), 200ul, >10^7 TU/mL
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CNY 21,470.00
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Specifications
| Product Data | |
| Product Name | Flt4 (NM_008029) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI323512; Chy; Flt-4; VEGFR-3; VEGFR3 |
| Vector | pLenti-C-mGFP |
| ACCN | NM_008029 |
| ORF Size | 4089 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR225313).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008029.3, NP_032055.1 |
| RefSeq Size | 5853 bp |
| RefSeq ORF | 4092 bp |
| Locus ID | 14257 |
| Gene Summary | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.[UniProtKB/Swiss-Prot Function] |
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