Foxo1 (NM_019739) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR227240L2V
- LentiORF®
-
Lenti ORF particles, Foxo1 (GFP-tagged) - Mouse forkhead box O1 (Foxo1), 200ul, >10^7 TU/mL
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CNY 12,540.00
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Specifications
Product Data | |
Product Name | Foxo1 (NM_019739) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | Afxh; AI876417; FKHR; Fkhr1; Foxo1a |
Vector | pLenti-C-mGFP |
ACCN | NM_019739 |
ORF Size | 1956 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR227240).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_019739.3, NP_062713.2 |
RefSeq Size | 5552 bp |
RefSeq ORF | 1959 bp |
Locus ID | 56458 |
Gene Summary | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).[UniProtKB/Swiss-Prot Function] |
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