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LDL Receptor (LDLR) (NM_000527) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC200006L1V
- LentiORF®
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Lenti ORF particles, LDLR (Myc-DDK tagged) - Human low density lipoprotein receptor (LDLR), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 8,930.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Product Name | LDL Receptor (LDLR) (NM_000527) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | FH; FHC; FHCL1; LDLCQ2 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_000527 |
| ORF Size | 2580 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC200006).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_000527.2, NP_000518.1 |
| RefSeq Size | 5175 bp |
| RefSeq ORF | 2583 bp |
| Locus ID | 3949 |
| Domains | ldl_recept_b, EGF_CA, ldl_recept_a, EGF, EGF |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Endocytosis |
| MW | 95.38 kDa |
| Gene Summary | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Release of Vesicular Stomatitis Virus Spike Protein G-Pseudotyped Lentivirus from the Host Cell Is Impaired upon Low-Density Lipoprotein Receptor Overexpression
,null,
Journal of Virology
,PubMed ID 26339060
[LDLR]
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