COX2 (PTGS2) (NM_000963) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC202245L1V
- LentiORF®
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Lenti ORF particles, PTGS2 (Myc-DDK tagged) - Human prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2), 200ul, >10^7 TU/mL
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CNY 8,930.00
Cited in 4 publications. |
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CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Product Name | COX2 (PTGS2) (NM_000963) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_000963 |
ORF Size | 1812 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC202245).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_000963.1 |
RefSeq Size | 4465 bp |
RefSeq ORF | 1815 bp |
Locus ID | 5743 |
Domains | An_peroxidase, EGF |
Protein Families | Druggable Genome |
Protein Pathways | Arachidonic acid metabolism, Pathways in cancer, Small cell lung cancer, VEGF signaling pathway |
MW | 69 kDa |
Gene Summary | Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] |
Citations (4)
The use of this cDNA Clones has been cited in the following citations: |
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Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor
,null,
Scientific Reports
,PubMed ID 30420769
[PTGS2]
|
Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis.
,null,
Cancer letters
,PubMed ID 28043910
[PTGS2]
|
P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene.
,null,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
,PubMed ID 26476537
[PTGS2]
|
Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes
,null,
Molecular Carcinogenesis
,PubMed ID 19148897
[PTGS2]
|
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