United States
Germany
Japan
United Kingdom
China
BRSK1 (NM_032430) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC211767L3V
- LentiORF®
-
Lenti ORF particles, BRSK1 (Myc-DDK-tagged)-Human BR serine/threonine kinase 1 (BRSK1), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 14,440.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | BRSK1 (NM_032430) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | hSAD1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_032430 |
| ORF Size | 2334 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC211767).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_032430.1 |
| RefSeq Size | 3109 bp |
| RefSeq ORF | 2337 bp |
| Locus ID | 84446 |
| Protein Families | Druggable Genome, Protein Kinase |
| MW | 84.9 kDa |
| Gene Summary | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
