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SENP6 (NM_001100409) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC217424L3V
- LentiORF®
-
Lenti ORF particles, SENP6 (Myc-DDK-tagged)-Human SUMO1/sentrin specific peptidase 6 (SENP6), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 11,210.00
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Specifications
| Product Data | |
| Product Name | SENP6 (NM_001100409) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | SSP1; SUSP1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001100409 |
| ORF Size | 3315 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC217424).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001100409.1 |
| RefSeq Size | 6624 bp |
| RefSeq ORF | 3318 bp |
| Locus ID | 26054 |
| Protein Families | Druggable Genome, Protease |
| MW | 125.2 kDa |
| Gene Summary | Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] |
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