CD11b (ITGAM) (NM_000632) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC221743L3V
- LentiORF®
Lenti ORF particles, ITGAM (Myc-DDK tagged) - Human integrin, alpha M (complement component 3 receptor 3 subunit) (ITGAM), transcript variant 2, 200ul, >10^7 TU/mL
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Specifications
Product Data | |
Product Name | CD11b (ITGAM) (NM_000632) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_000632 |
ORF Size | 3456 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC221743).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_000632.2 |
RefSeq Size | 4740 bp |
RefSeq ORF | 3459 bp |
Locus ID | 3684 |
Domains | FG-GAP, VWA |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton |
MW | 127.18 kDa |
Gene Summary | This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
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