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ZNF207 (NM_003457) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC223933L3V
- LentiORF®
-
Lenti ORF particles, ZNF207 (Myc-DDK-tagged)-Human zinc finger protein 207 (ZNF207), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 9,310.00
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| Product Data | |
| Product Name | ZNF207 (NM_003457) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | BuGZ; hBuGZ |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_003457 |
| ORF Size | 1434 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC223933).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_003457.1 |
| RefSeq Size | 2347 bp |
| RefSeq ORF | 1437 bp |
| Locus ID | 7756 |
| Domains | zf-C2H2 |
| Protein Families | Transcription Factors |
| MW | 50.6 kDa |
| Gene Summary | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).[UniProtKB/Swiss-Prot Function] |
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