NRG3 (NM_001010848) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC224735L4V
- LentiORF®
Lenti ORF particles, NRG3 (mGFP-tagged)-Human neuregulin 3 (NRG3), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
Product Data | |
Product Name | NRG3 (NM_001010848) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | HRG3; pro-NRG3 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_001010848 |
ORF Size | 2088 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC224735).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001010848.3 |
RefSeq Size | 3692 bp |
RefSeq ORF | 2091 bp |
Locus ID | 10718 |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | ErbB signaling pathway |
MW | 75 kDa |
Gene Summary | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] |
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