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NRG3 (NM_001010848) Human Untagged Clone
CAT＃: SC301476
NRG3 (untagged)-Human neuregulin 3 (NRG3), transcript variant 1
CNY 7,656.00
货期*
现货
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HRG3; pro-NRG3 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_001010848 edited
ATGAGTGAAGGGGCGGCCGCTGCCTCGCCACCTGGTGCCGCTTCGGCAGCCGCCGCCTCG GCCGAGGAGGGCACCGCGGCGGCTGCGGCGGCGGCAGCGGCGGGCGGGGGCCCGGACGGC GGCGGCGAAGGGGCGGCCGAGCCCCCCCGGGAGTTACGCTGTAGCGACTGCATCGTGTGG AACCGGCAGCAGACGTGGCTGTGCGTGGTACCTCTGTTCATCGGCTTCATCGGCCTGGGG CTCAGCCTCATGCTTCTCAAATGGATCGTGGTGGGCTCCGTCAAGGAGTACGTGCCCACC GACCTAGTGGACTCCAAGGGGATGGGCCAGGACCCCTTCTTCCTCTCCAAGCCCAGCTCT TTCCCCAAGGCCATGGAGACCACCACCACTACCACTTCCACCACGTCCCCCGCCACCCCC TCCGCCGGGGGTGCCGCCTCCTCCAGGACGCCCAACCGGATTAGCACTCGCCTGACCACC ATCACGCGGGCGCCCACTCGCTTCCCCGGGCACCGGGTGCCCATCCGGGCCAGCCCGCGC TCCACCACAGCACGGAACACTGCGGCCCCTGCGACGGTCCCGTCCACCACGGCCCCGTTC TTCAGTAGCAGCACGCTGGGCTCCCGACCCCCGGTGCCAGGAACTCCAAGTACCCAGGCA ATGCCCTCCTGGCCTACTGCGGCATACGCTACCTCCTCCTACCTTCACGATTCTACTCCC TCCTGGACCCTGTCTCCCTTTCAGGATGCTGCCTCCTCTTCTTCCTCTTCTTCCTCCTCC GCTACCACCACCACACCAGAAACTAGCACCAGCCCCAAATTTCATACGACGACATATTCC ACAGAGCGATCCGAGCACTTCAAACCCTGCCGAGACAAGGACCTTGCATACTGTCTCAAT GATGGCGAGTGCTTTGTGATCGAAACCCTGACCGGATCCCATAAACACTGTCGGTGCAAA GAAGGCTACCAAGGAGTCCGTTGTGATCAATTTCTGCCGAAAACTGATTCCATCTTATCG GATCCAAACCACTTGGGGATTGAATTCATGGAGAGTGAAGAAGTTTATCAAAGGCAGGTG CTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTC TACTTCAAAAGCAAGAAACAAGCTAAACAAATCCAAGAGCAGCTGAAAGTGCCACAAAAT GGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAAG AGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAG AAAATGATGGAGTCAAGTTTTGTCGGCCCCCAGTCATTCCCTGAGGTCCCTTCTCCTGAC AGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCAA AGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGG CTAGGTGGAATTGTGGGACCAGCATATCAGCAACTCGAAGAATCAAGGATCCCAGACCAG GATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATCA ATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAG GACCTGGTGGGCTATTCATCCACAAGGGCCAGTTCTGTGCCCATCATCCCTTCAGTGGGT TTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTGC AAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATA GCAGAACAACAAGAAGTGAAAATATTGCTAGAAACTGTCCAGGAGCAGATCCGAATTCTG ACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGCA AGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAA TTTGTCTTAAGAAATGAAATACAAAGAGACTCTGCATTGACCAAGTGA >OriGene 5' read for NM_001010848 unedited
GTAAACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCAGGGAGCGGATTTGCATGC GGCCGCCGCGGCCGCTGCCTGCGCCCGAGCCCGCCGCCGCCGCCGGAGCCCGCGCCCGCG CCCGCGCCCGGCCCGCGCGGCCCCATGCCTCTGCCGCGGCCCTCGGGGGGGCGAAGGTGA AGACCGGCTCCTAGGATGAGTGAAGGGGCGGCCGCTGCCTCGCCACCTGGTGCCGCTTCG GCAGCCGCCGCCTCGGCCGAGGAGGGCACCGCGGCGGCTGCGGCGGCGGCAGCGGCGGGC GGGGGCCCGGACGGCGGCGGCGAAGGGGCGGCCGAGCCCCCCCGGGAGTTACGCTGTAGC GACTGCATCGTGTGGAACCGGCAGCAGACGTGGCTGTGCGTGGTACCTCTGTTCATCGGC TTCATCGGCCTGGGGCTCAGCCTCATGCTTCTCAAATGGATCGTGGTGGGCTCCGTCAAG GAGTACGTGCCCACCGACCTAGTGGACTCCAAGGGGATGGGCCAGGACCCCTTCTTCCTC TCCAAGCCCAGCTCTTTCCCCAAGGCCATGGAGACCACCACCACTACCACTTNCACCACG TNCCCCGCCACCCCCTCCGCCGGGGGTGCCGCCTCCTCCAGGACGCCCAACCGGATTAGC ACTCGCCTGACCACCATCACGCGGGCGCCCACTCGCTTTCCCGGCACCGGGTGCCCATCC GGGCCAGCCCGCGCTTCACCACAGCACGGAACACTGCGGCCCCTGCGACGGTCCCGTCCA CCACGGNCCCGGTTCTCAGTAGCAGCACGCTGGGCTTCCGACCCCCGGTGCCCAGAACTC CAAGTACCCAGCCAATGCCTCCTGGCCTACTGCGCATACGCTACC >OriGene 3' genomic read for NM_001010848 unedited
AAGGTCCATCTATGNANCGCGGCACGCATTCCANGATCGGTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTGCTTTCAAATAACGGGGCCTTTTTATTTAAAACAGG GGAAACATAACAACTCAACCCCCCCAATAATTGGGAAAAAAACTGGGTATGGGAACCCTA ATTTCCCCATATGTCCCATGAAAGTGAGGGGAAATAAACAGACCAATCTTCAGGAAAGGT TTCAGTTCACCTTAACAGGGGGAAAAATATTGGTTTATTCCCAATGAACCTTCCACACAA TTTACTGTTCTTTTGGGGGGCTTCTTGGGAACCGAATAATCTGGGGATTTTTATTTCAAC AATTTATTTTTCCCCTACTAACCCCAGAAGCCCAAGCCTTGGTCCACACATAGCAAACTT GCTTTAAAATAAATGGGAATGAGGGTGATGAGAAAGCCAATGGGAACCGGCAATTTGGTA ATTGGCTTGGGTTAATAATTTAAGGAGGCCTGATTCAAAATAAACACCCCTCCCTGATGA ACCCACCTTATGATACCGGTATCATTAATGAGCCCATAGTTGATCCCCTCAAAAGTATTC ACATCAAAAAATGGGCTAAACAGTGTCAAAAGTTTTATACGACCCCCCCCTGCCAGTGAC CCTGATTTAAGAACTAACTGAACTTTTACTTAATGGAAAAATTTTAAGGGGAAAGATCTT AGAGGGAAAAATTTTTTCTGAATAGAAGATTCCCCGGAGGGTTCAAAAAAATTTTAACAA GCGTAATTACCCGCACACTGGCCCACCCTTCCCCCCATGAAAACCTGGGCTACAACATAT GTTGCCCCCGTGAACAATCCCCACACACCCCCCCCCC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001010848 |
| Insert Size | 4000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | There are 4 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 1 amino acid and deletion of 1 amino acid. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001010848.2, NP_001010848.2 |
| RefSeq Size | 2091 bp |
| RefSeq ORF | 2091 bp |
| Locus ID | 10718 |
| UniProt ID | P56975 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | ErbB signaling pathway |
| Gene Summary | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] Transcript Variant: This variant (1) encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC224735 | NRG3 (Myc-DDK-tagged)-Human neuregulin 3 (NRG3), transcript variant 1 |
CNY 8,152.00 |
|
| RC224735L3 | Lenti-ORF clone of NRG3 (Myc-DDK-tagged)-Human neuregulin 3 (NRG3), transcript variant 1 |
CNY 5,890.00 |
|
| RC224735L4 | Lenti-ORF clone of NRG3 (mGFP-tagged)-Human neuregulin 3 (NRG3), transcript variant 1 |
CNY 5,890.00 |
|
| RG224735 | NRG3 (tGFP-tagged) - Human neuregulin 3 (NRG3), transcript variant 1 |
CNY 9,752.00 |
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