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ALS2 (NM_001135745) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC226660L3V
- LentiORF®
-
Lenti ORF particles, ALS2 (Myc-DDK tagged) - Human amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | ALS2 (NM_001135745) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ALS2CR6; ALSJ; IAHSP; PLSJ |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001135745 |
| ORF Size | 1188 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC226660).
|
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001135745.1 |
| RefSeq ORF | 1191 bp |
| Locus ID | 57679 |
| Protein Families | Druggable Genome |
| Protein Pathways | Amyotrophic lateral sclerosis (ALS) |
| MW | 42.4 kDa |
| Gene Summary | The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
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