JMY (NM_152405) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC229401L3V
- LentiORF®
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Lenti ORF particles, JMY (Myc-DDK tagged) - Human junction mediating and regulatory protein, p53 cofactor (JMY), 200ul, >10^7 TU/mL
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CNY 17,290.00
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Specifications
Product Data | |
Product Name | JMY (NM_152405) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | WHAMM2; WHDC1L3 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_152405 |
ORF Size | 2964 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC229401).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_152405.3, NP_689618.3 |
RefSeq ORF | 2967 bp |
Locus ID | 133746 |
MW | 111.3 kDa |
Gene Summary | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).[UniProtKB/Swiss-Prot Function] |
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