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Opa1 (NM_133585) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR205659L3V
- LentiORF®
-
Lenti ORF particles, Opa1 (Myc-DDK-tagged ORF) - Rat optic atrophy 1 homolog (human) (Opa1), nuclear gene encoding mitochondrial protein, 200ul, >10^7 TU/mL
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CNY 14,754.00
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Specifications
| Product Data | |
| Product Name | Opa1 (NM_133585) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | MGC124921 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_133585 |
| ORF Size | 2880 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR205659).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_133585.3, NP_598269.3 |
| RefSeq Size | 3200 bp |
| RefSeq ORF | 2883 bp |
| Locus ID | 171116 |
| Gene Summary | Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (By similarity).[UniProtKB/Swiss-Prot Function] |
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