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Prkra (NM_001024780) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR209032L3V
- LentiORF®
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Lenti ORF particles, Prkra (Myc-DDK-tagged ORF) - Rat protein kinase, interferon inducible double stranded RNA dependent activator (Prkra), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Prkra (NM_001024780) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | RAX |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001024780 |
| ORF Size | 939 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR209032).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001024780.1, NP_001019951.1 |
| RefSeq Size | 1589 bp |
| RefSeq ORF | 942 bp |
| Locus ID | 311130 |
| Gene Summary | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association, sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).[UniProtKB/Swiss-Prot Function] |
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