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Map3k7 (NM_001107920) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR212444L4V
- LentiORF®
-
Lenti ORF particles, Map3k7 (GFP-tagged ORF) - Rat mitogen activated protein kinase kinase kinase 7 (Map3k7), 200ul, >10^7 TU/mL
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CNY 10,355.00
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Specifications
| Product Data | |
| Product Name | Map3k7 (NM_001107920) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | Tak1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001107920 |
| ORF Size | 1818 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR212444).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001107920.2, NP_001101390.2 |
| RefSeq Size | 4540 bp |
| RefSeq ORF | 1821 bp |
| Locus ID | 313121 |
| Gene Summary | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (By similarity). Promotes TRIM5 capsid-specific restriction activity (By similarity).[UniProtKB/Swiss-Prot Function] |
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