Human Dopamine beta Hydroxylase (DBH) activation kit by CRISPRa
CAT#: GA101143
DBH CRISPRa kit - CRISPR gene activation of human dopamine beta-hydroxylase
CNY 12,255.00
CNY 6,281.00
CNY 4,592.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | DBH |
Locus ID | 1621 |
Kit Components | GA101143G1, Dopamine beta Hydroxylase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101143G2, Dopamine beta Hydroxylase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101143G3, Dopamine beta Hydroxylase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_000787 |
Synonyms | DBM |
Summary | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN212355 | DBH - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
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KN212355BN | DBH - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
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KN212355LP | DBH - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN212355RB | DBH - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN412355 | DBH - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |