Dopamine beta Hydroxylase (DBH) Human Gene Knockout Kit (CRISPR)
CAT#: KN212355BN
DBH - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
CNY 3,710.00
CNY 6,281.00
CNY 4,592.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | Dopamine beta Hydroxylase |
Locus ID | 1621 |
Kit Components |
KN212355G1, Dopamine beta Hydroxylase gRNA vector 1 in pCas-Guide CRISPR vector KN212355G2, Dopamine beta Hydroxylase gRNA vector 2 in pCas-Guide CRISPR vector KN212355BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_000787 |
Synonyms | DBM |
Summary | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017] |
Documents
Product Manuals |
FAQs |
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN212355 | DBH - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN212355LP | DBH - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN212355RB | DBH - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN412355 | DBH - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
|
GA101143 | DBH CRISPRa kit - CRISPR gene activation of human dopamine beta-hydroxylase |
CNY 12,255.00 |
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