Human HLA-DRB4 activation kit by CRISPRa
CAT#: GA102135
HLA-DRB4 CRISPRa kit - CRISPR gene activation of human major histocompatibility complex, class II, DR beta 4
CNY 12,255.00
货期*
4周
规格
经常一起买 (2)
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | HLA-DRB4 |
Locus ID | 3126 |
Kit Components | GA102135G1, HLA-DRB4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102135G2, HLA-DRB4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102135G3, HLA-DRB4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_021983 |
Synonyms | class II histocompatibility antigen HLA DR alpha, beta1-0307; DRB1 transplantation antigen; DRB4; HLA-DR4B; HLA DRB1*1202; MHC class2 antig; MHC class II antigen HLA-DR-beta; MHC class II antigen HLA-DRB1; MHC class II HLA-DR-beta-7; MHC HLA DR-beta chain |
Summary | HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020] |
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基因表达相关资源 |
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