Human MITF activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MITF
Locus ID	4286
Kit Components	GA102913G1, MITF gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102913G2, MITF gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102913G3, MITF gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000248, NM_001184967, NM_001184968, NM_006722, NM_198158, NM_198159, NM_198177, NM_198178, NM_001354604, NM_001354605, NM_001354606, NM_001354607, NM_001354608
Synonyms	bHLHe32; CMM8; MI; WS2; WS2A
Summary	The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]

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