Human PBX1 activation kit by CRISPRa

CAT#: GA103399

PBX1 CRISPRa kit - CRISPR gene activation of human PBX homeobox 1



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
PBX1 mouse monoclonal antibody, clone OTI1C11 (formerly 1C11)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


PBX1 (Myc-DDK-tagged)-Human pre-B-cell leukemia homeobox 1 (PBX1), transcript variant 1
    • 10 ug

CNY 3,656.00
CNY 3,990.00


PBX1 mouse monoclonal antibody, clone OTI4D1 (formerly 4D1)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol PBX1
Locus ID 5087
Kit Components

GA103399G1, PBX1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103399G2, PBX1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103399G3, PBX1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001204961, NM_001204963, NM_002585, NM_001353130, NM_001353131
Synonyms DKFZp686B09108; MGC126627
Summary This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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