Human PML Protein (PML) activation kit by CRISPRa

CAT#: GA103626

PML CRISPRa kit - CRISPR gene activation of human promyelocytic leukemia



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (2)
Rabbit monoclonal anti-PML antibody for SISCAPA, clone OTIR1H2
    • 100 ul

CNY 4,390.00


PML (Myc-DDK-tagged)-Human promyelocytic leukemia (PML), transcript variant 5
    • 10 ug

CNY 4,168.00
CNY 4,560.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol PML
Locus ID 5371
Kit Components

GA103626G1, PML Protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103626G2, PML Protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103626G3, PML Protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_002675, NM_033238, NM_033239, NM_033240, NM_033242, NM_033244, NM_033245, NM_033246, NM_033247, NM_033249, NM_033250
Synonyms MYL; PP8675; RNF71; TRIM19
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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