Human alpha Synuclein (SNCA) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SNCA
Locus ID	6622
Kit Components	GA104535G1, alpha Synuclein gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104535G2, alpha Synuclein gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104535G3, alpha Synuclein gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000345, NM_001146054, NM_001146055, NM_007308
Synonyms	NACP; PARK1; PARK4; PD1
Summary	Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

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