Human Wilms Tumor Protein (WT1) activation kit by CRISPRa

CAT#: GA105163

WT1 CRISPRa kit - CRISPR gene activation of human WT1 transcription factor



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
Rabbit monoclonal anti-WT1 Antibody, clone OTIR5F11
    • 100 ul

CNY 4,390.00


WT1 (Myc-DDK-tagged)-Human Wilms tumor 1 (WT1), transcript variant A
    • 10 ug

CNY 3,656.00
CNY 4,370.00


Rabbit monoclonal anti-WT1 Antibody, clone OTIR5F11
    • 30 ul

CNY 1,140.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol WT1
Locus ID 7490
Kit Components

GA105163G1, Wilms Tumor Protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105163G2, Wilms Tumor Protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105163G3, Wilms Tumor Protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000378, NM_001198551, NM_001198552, NM_024424, NM_024425, NM_024426, NM_001367854, NR_160306
Synonyms AWT1; EWS-WT1; GUD; NPHS4; WAGR; WIT-2; WT33
Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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