Human Ephexin 1 (NGEF) activation kit by CRISPRa

CAT#: GA108537

NGEF CRISPRa kit - CRISPR gene activation of human neuronal guanine nucleotide exchange factor



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
NGEF rabbit polyclonal antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


NGEF (Myc-DDK-tagged)-Human neuronal guanine nucleotide exchange factor (NGEF), transcript variant 1
    • 10 ug

CNY 5,200.00
CNY 5,800.00


NGEF Rabbit polyclonal Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol NGEF
Locus ID 25791
Kit Components

GA108537G1, Ephexin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108537G2, Ephexin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108537G3, Ephexin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001114090, NM_019850
Synonyms ARHGEF27; EPHEXIN
Summary Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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