Human NRDE2 activation kit by CRISPRa
CAT#: GA110479
NRDE2 CRISPRa kit - CRISPR gene activation of human NRDE-2, necessary for RNA interference, domain containing
CNY 12,255.00
CNY 12,160.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | NRDE2 |
Locus ID | 55051 |
Kit Components | GA110479G1, NRDE2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110479G2, NRDE2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110479G3, NRDE2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_017970, NM_199043 |
Synonyms | C14orf102 |
Summary | Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |