Human Artemis (DCLRE1C) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DCLRE1C
Locus ID	64421
Kit Components	GA112072G1, Artemis gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112072G2, Artemis gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112072G3, Artemis gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001033855, NM_001033857, NM_001033858, NM_001289076, NM_001289077, NM_001289078, NM_001289079, NM_022487, NR_110297, NM_001350965, NM_001350966, NM_001350967, NR_146960, NR_146961, NR_146962
Synonyms	A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C
Summary	This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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