Human Apoptosis enhancing nuclease (AEN) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	AEN
Locus ID	64782
Kit Components	GA112143G1, Apoptosis enhancing nuclease gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112143G2, Apoptosis enhancing nuclease gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112143G3, Apoptosis enhancing nuclease gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_022767
Synonyms	ISG20L1; pp12744
Summary	Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.[UniProtKB/Swiss-Prot Function]

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