Human BRCC36 (BRCC3) activation kit by CRISPRa
CAT#: GA112410
BRCC3 CRISPRa kit - CRISPR gene activation of human BRCA1/BRCA2-containing complex subunit 3
CNY 12,255.00
CNY 1,999.00
CNY 2,700.00
CNY 2,400.00
CNY 4,465.00
CNY 800.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | BRCC3 |
Locus ID | 79184 |
Kit Components | GA112410G1, BRCC36 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112410G2, BRCC36 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112410G3, BRCC36 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001018055, NM_001242640, NM_024332 |
Synonyms | BRCC36; C6.1A; CXorf53 |
Summary | This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN400727 | BRCC3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |