Human PPP1R15B activation kit by CRISPRa

CAT#: GA113767

PPP1R15B CRISPRa kit - CRISPR gene activation of human protein phosphatase 1 regulatory subunit 15B



  See Other Versions

CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (2)
Rabbit Polyclonal Anti-PPP1R15B Antibody
    • 100 ul

CNY 5,250.00


PPP1R15B (Myc-DDK-tagged)-Human protein phosphatase 1, regulatory (inhibitor) subunit 15B (PPP1R15B)
    • 10 ug

CNY 5,224.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol PPP1R15B
Locus ID 84919
Kit Components

GA113767G1, PPP1R15B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA113767G2, PPP1R15B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA113767G3, PPP1R15B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_032833
Synonyms CREP; MSSGM2
Summary This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents

Other Versions

Customer Reviews 
Loading...