Human TIRAP activation kit by CRISPRa
CAT#: GA114439
TIRAP CRISPRa kit - CRISPR gene activation of human TIR domain containing adaptor protein
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | TIRAP |
Locus ID | 114609 |
Kit Components | GA114439G1, TIRAP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114439G2, TIRAP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114439G3, TIRAP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001039661, NM_001318776, NM_001318777, NM_052887, NM_148910 |
Synonyms | BACTS1; Mal; MyD88-2; wyatt |
Summary | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN407162 | TIRAP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |