Human ZDHHC21 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZDHHC21
Locus ID	340481
Kit Components	GA117481G1, ZDHHC21 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117481G2, ZDHHC21 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117481G3, ZDHHC21 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_178566, NM_001354118, NM_001354119, NM_001354120, NM_001354121, NM_001354122, NM_001354123, NM_001354124, NM_001354125, NM_001354126, NM_001354127, NM_001354128, NM_001354129, NM_001354130, NR_148714, NR_148715, NR_148716, NR_148717, NR_148718
Synonyms	9130404H11Rik; DHHC-21; DHHC21; DNZ1; HSPC097
Summary	Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).[UniProtKB/Swiss-Prot Function]

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