Mouse Apaf1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Apaf1
Locus ID	11783
Kit Components	GA200220G1, Apaf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200220G2, Apaf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200220G3, Apaf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001042558, NM_001282947, NM_009684
Synonyms	6230400I06Rik; Apaf-1; Apaf1l; fog; mKIAA0413
Summary	Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).[UniProtKB/Swiss-Prot Function]

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