Mouse Bcl10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Bcl10
Locus ID	12042
Kit Components	GA200381G1, Bcl10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200381G2, Bcl10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200381G3, Bcl10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_009740
Synonyms	AI132454; BCL-10; C81403; CARMEN; cE10; CIPER; CLAP; ME10
Summary	Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.[UniProtKB/Swiss-Prot Function]

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