Mouse Cacna1d activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cacna1d
Locus ID	12289
Kit Components	GA200478G1, Cacna1d gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200478G2, Cacna1d gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200478G3, Cacna1d gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001083616, NM_001302637, NM_028981
Synonyms	8430418G19Rik; C79217; Cach3; Cacn4; Cacnl1a2; Cav1.3; Cchl1a; Cchl1a2; D-LTCC
Summary	This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

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