Mouse Herc2 activation kit by CRISPRa
CAT#: GA201875
Herc2 CRISPRa kit - CRISPR gene activation of mouse HECT and RLD domain containing E3 ubiquitin protein ligase 2
CNY 12,255.00
货期*
4周
规格
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Herc2 |
Locus ID | 15204 |
Kit Components | GA201875G1, Herc2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201875G2, Herc2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201875G3, Herc2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_010418, NM_001360080 |
Synonyms | D7H15F32S1; D7H15F37S1; D15F32S1h; jdf2; mKIAA0393; rjs |
Summary | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
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