Mouse Kcnj3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kcnj3
Locus ID	16519
Kit Components	GA202269G1, Kcnj3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202269G2, Kcnj3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202269G3, Kcnj3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001304810, NM_008426, NM_001355118
Synonyms	GIRK-1; GIRK1; Kcnf3; Kir3.1
Summary	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.[UniProtKB/Swiss-Prot Function]

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