Mouse Tnc activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tnc
Locus ID	21923
Kit Components	GA204382G1, Tnc gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204382G2, Tnc gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204382G3, Tnc gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_011607, NM_001369211, NM_001369212, NM_001369213, NM_001369214
Synonyms	AI528729; C130033P17Rik; cytotactin; Hxb; Ten; tenascin-C; TN; TN-C
Summary	Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).[UniProtKB/Swiss-Prot Function]

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