Mouse Pidd1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pidd1
Locus ID	57913
Kit Components	GA206242G1, Pidd1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206242G2, Pidd1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206242G3, Pidd1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_022654, NM_001360523, NM_001360524, NR_153591
Synonyms	1200011D09Rik; AU042446; Lrdd; Pidd
Summary	Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity).[UniProtKB/Swiss-Prot Function]

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